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Interactive 3-D structures of immune effector and pathogen molecules.

COVID 19 Spike Complex Cryo-EM Structures Influenza Virus Hemaglutinin (HA) Structure

COVID19 Spike Complex with all 3 RBDs "Down" or "Closed" (pH = 5.5)

Flu Virus Hemagglutinin (HA) Antigenic Structure
COVID19 Spike Complex with 1 RBD of 3 "Up" or "Open" (pH = 5.5) Human Immunodeficiency Virus (HIV) Protease Structure
COVID19 Spike Complex with 3 RBDs "Up" and Bound to ACE2" (pH = 7.4) Human Immunodeficiency Virus (HIV): Protease + Inhibitor
Antibody Domain Structures T Cell Receptor Domain Structires
Human IgG1 Domain Overview TCR Domain Overview
Human IgG1 Domains TCR Alpha/Beta Dimer
VL-VH Domain Interactions TCR Interdomain Interactions
CL-CH1 Domain Interactions + Interchain H-L Disulfide TCR Hypervariable Regions
Hinge Region + Interchain H-H Disulfides T Cell Receptor / MHC I / Peptide Complex
CH2-CH2 Domains + Carbohydrate Interactions TCR / H-2Kb / dEBV Peptide Complex
CH3-CH3 Domain Interactions Mechanisms of Antibody and T Cell Receptor Diversification
Antibody-Antigen Interactions V-J Joining: Junctional Diversification by Alternate DNA Joining
Monoclonal Fab / Hen Egg-White Lysozyme Complex Catlytic Antibodies
Two Monoclonal Fab / Hen Egg-White Lysozyme Complexes Catalytic Antibody: Mouse Monoclonal Abzyme + Hapten
MHC Class I: Human HLA-A2, B2, or Mouse H-2K MHC Class II: Human HLA-DR1 or DR3
HLA-A2 / (CD8α)2 / HIV RTase Peptide Complex HLA-DR1 / CD4 / Flu Virus Peptide Complex
  HLA-B*1402 / EBV LMP2 Peptide Complex HLA-DR1 / Flu Virus Peptide Complex
  HLA-B*2705 / Complexes with Viral or Self Peptides HLA-DR1 / (Ala)13 Peptide Complex
H-2Kb / SEV-9 Peptide Complex HLA-DR1 / Staph Enterotoxin B (SEB) Super Antigen Complex
  H-2Kb / SEV-9 or OVA-8 Peptide Complexes   HLA-DR3 / CLIP (Class II Associated Invariant Chain) Peptide Complex
Human Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing
Ligand or TRAIL Cytokine / Death Receptor 5 (DR5) Complex
TRAIL Cytokine / DR5 Receptor Complex

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©Duane W. Sears
Revised: February 12, 2023