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Interactive 3-D structures of immune effector and pathogen molecules.
COVID 19 Spike Complex Cryo-EM Structures
Influenza Virus Hemaglutinin (HA) Structure
COVID19 Spike Complex with all 3 RBDs "Down" or "Closed"
(pH = 5.5)
Flu Virus Hemagglutinin (HA) Antigenic Structure
COVID19 Spike Complex with 1 RBD of 3 "Up" or "Open" (pH = 5.5)
Human Immunodeficiency Virus (HIV) Protease Structure
COVID19 Spike Complex with 3 RBDs "Up" and Bound to ACE2" (pH = 7.4)
Human Immunodeficiency Virus (HIV): Protease + Inhibitor
Antibody Domain Structures
T Cell Receptor Domain Structires
Human IgG1 Domain Overview
TCR Domain Overview
Human IgG1 Domains
TCR Alpha/Beta Dimer
V
L
-V
H
Domain Interactions
TCR Interdomain Interactions
C
L
-C
H
1 Domain Interactions + Interchain H-L Disulfide
TCR Hypervariable Regions
Hinge Region + Interchain H-H Disulfides
T Cell Receptor / MHC I / Peptide Complex
C
H
2-C
H
2 Domains + Carbohydrate Interactions
TCR / H-2K
b
/ dEBV Peptide Complex
C
H
3-C
H
3 Domain Interactions
Mechanisms of Antibody and T Cell Receptor Diversification
Antibody-Antigen Interactions
V-J Joining: Junctional Diversification by Alternate DNA Joining
Monoclonal Fab / Hen Egg-White Lysozyme Complex
Catlytic Antibodies
Two Monoclonal Fab / Hen Egg-White Lysozyme Complexes
Catalytic Antibody: Mouse Monoclonal Abzyme + Hapten
MHC Class I: Human HLA-A2, B2, or Mouse H-2K
MHC Class II: Human HLA-DR1 or DR3
HLA-A2 / (CD8α)
2
/ HIV RTase Peptide Complex
HLA-DR1 / CD4 / Flu Virus Peptide Complex
HLA-B*1402 / EBV LMP2 Peptide Complex
HLA-DR1 / Flu Virus Peptide Complex
HLA-B*2705 / Complexes with Viral or Self Peptides
HLA-DR1 / (Ala)
13
Peptide Complex
H-2K
b
/ SEV-9 Peptide Complex
HLA-DR1 / Staph Enterotoxin B (SEB) Super Antigen Complex
H-2K
b
/ SEV-9 or OVA-8 Peptide Complexes
HLA-DR3 / CLIP (Class II Associated Invariant Chain) Peptide Complex
Human Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing
Ligand or TRAIL Cytokine / Death Receptor 5 (DR5) Complex
TRAIL Cytokine / DR5 Receptor Complex
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©
Duane W. Sears
Revised: February 12, 2023