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Three pH Rate Profile Models Graphical Models for Enzymatic pH Rate Profiles

kcat' = Yd1*Ya2 *kcat

kcat' = Yd1*kcat & Km' = Km/Ya2

kcat' = Yd1*Ya2*kcat & Km' = Km/(Yd1*Ya)

Enzyme Catalytic Activity and Inhibition Enzyme pH Rate Profiles

Chymotrypsin (Serine Endopeptidase) +/- Covalent Inhibitor

Chymotrypsin Inhibitor Complex

Chymotrypsinogen A Conversion to Chymotrypsin

pH Rate Kinetic Profiles for Chymotrypsin (Excel)

 

 

Hen Egg-white Lysozyme (Endogycosidase) +/- Competitve Inhibitor

Lysozyme-Inhibitor Complex

Chicken Lysozyme Overview

Chicken (Hen Egg White - HEW) Lysozyme

Human Lysozyme Substrate Complex

Differential Titration of the Single His Residue in Hen Egg-White Lysozyme and in Human Lysozyme

pH Rate Kinetic Profiles for HEW Lysozyme (Excel)

 

 
HIV Protease Inhibitor bound to
Catalytic Site Asp Residues



HIV inhibitor complex

HIV aspartyl protease pH rate profile
 
Pepsin Catalytic Site Asp Residues



Pepsin inhibitor complex

Pepsin aspartyl protease pH rate profile
 

 

 


 
Enzyme Inhibition-Self Assessment (MSOWCs)


©Duane W. Sears July 26, 2019