Contrasts Between Macromolecular Analysis by X-Ray Crystallography and Cryogeneic Electron Microscopy (Cryo-EM)
(A) Bowling balls passing through a tree forest. Tree trunks of different sizes are depicted by brown circles.
(B) X-ray diffraction by a homogenous crystallized lattice of molecules. Different atomic nuclei are depicted by brown circles.
(E) Single particle cryo-EM image processing workflow. Extended Data Fig. 5 . Z. Ke et al. Nature (2020) 588 pp. 498–502.
(F) Structural analysis of SARS-CoV-2 spike trimers on intact virions.
Fig. 2. Z. Ke et al. Nature 588 pp. 498–502 (2020).
(C) X‐ray photograph of a sperm whale myoglobin crystal.
J. Kendrew and M. Perutz, (late 1950s).
(D) Myoglobin alpha-helical electron density map.
Kendrew and Perutz (late 1950s).
© Duane W. Sears Revised: February 4, 2021   Z. Ke et al. "Cryo-EM analysis of the SARS-Cov-2 viron spike protein 3D conformations." Nature 488 pp. 498-502 (2020).