Model of human IgG
ANIMATED MODEL OF A COMPLETE IgG1 ANTIBODY MOLECULE human IgG1 model
L-H=H-L
(Fab)2
-----------
Fc
Fc Receptor
binding region
carbohydrate
References:
This model of human IgG1 was created by combining Brookhaven X-ray coordinate files for the antibody Fc (1fc2.pdb) and F(ab') (2ig2.pdb) fragments, where the latter coordinates were symmetrically rotated to generate the bivalent F(ab')2 arms (bio2ig2.pdb).
  1. E. A. Padlan. "Anatomy of the Antibody Molecule." Molecular Immunology 31:169 (1994).
The binding site on IgG1 for FcgRI was deduced by mutational studies:
  1. A. R. Duncan, J. M. Woof, L.J. Partridge, D. R. Burton, & G. Winter. "Localization of the binding site for the human high-affinity Fc receptor on IgG." Nature 332:563 (1988).
  2. S. M. Canfield & S. L. Morrison. The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region." Journal of Experimental Medicine 173:1483 (1991).
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© Duane W. Sears
Revised: October 07, 2010