Bivalent Amino Acid, Non-interactive Acid/Base Titration Equilibrium Reactionss

**Bivalent Standard Amino Acid with Non-interactive Acid/Base Titration Equilibrium Reactions**

Download the CDF Player: If the Wolfram Mathematica Computable Document Format (CDF) Player is not already installed on your computer, CLICK HERE to download the CDF Player installation file for your computer's operating system.
*Download the CDF activity file: After installing the CDF Player, CLICK HERE to download the CDF activity file for this exercise. When the file is opened with the Player, the first nested plot will appear, as illustrated by the static, screen-captured image below, and the pulldown menu can be used to navigate to the nested titration plots for the 13 bivalent standard amino acids* listed below with the empirially determined equilibrium dissociation constants for their alpha-amino groups (pK_N) and alpha-carboxyl groups (pK_C) indicated on each plot: Alanine Asparagine Glutamine Glycine Isoleucine Leucine Methonine Phenylalanine Proline Serine Threonine Tryptophan Valine
*Analysis of bivalent acid-base equilibrium reactions: The equilibrium acid/base titration of all 13 bivalent standard amino acids are analyzed as shown below in terms of the equilibrium association fraction (Y_A*) as a function of pH.

Bivalent Standard Amino Acid with Non-interactive Acid/Base Titration Equilibrium Reactions

Download the CDF Player: If the Wolfram Mathematica Computable Document Format (CDF) Player is not already installed on your computer, CLICK HERE to download the CDF Player installation file for your computer's operating system.

Download the CDF activity file: After installing the CDF Player, CLICK HERE to download the CDF activity file for this exercise. When the file is opened with the Player, the first nested plot will appear, as illustrated by the static, screen-captured image below, and the pulldown menu can be used to navigate to the nested titration plots for the 13 bivalent standard amino acids listed below with the empirially determined equilibrium dissociation constants for their alpha-amino groups (pK_N) and alpha-carboxyl groups (pK_C) indicated on each plot:

Alanine Asparagine Glutamine Glycine Isoleucine Leucine Methonine
Phenylalanine Proline Serine Threonine Tryptophan Valine

Analysis of bivalent acid-base equilibrium reactions: The equilibrium acid/base titration of all 13 bivalent standard amino acids are analyzed as shown below in terms of the equilibrium association fraction (Y_A) as a function of pH.